The personal and clinical utility of polygenic risk scores

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DNA methylation aging clocks: challenges and recommendations (2019, background): “lated risk for specific common diseases with genome-wide polygenic risk scores (PRSs) [116] with potential clinical utility [117].”
Improved polygenic prediction by Bayesian multiple regression on summary statistics (2019, methodology): “(5) In this paper we implement the BayesR model28,31, which assumes that 172”
Artificial intelligence in clinical and genomic diagnostics (2019, background): “Relatively simple statistical approaches to polygenic risk prediction allow for personally and clinically useful stratification of risk for some common complex diseases [77].”
Polygenic prediction of weight and obesity trajectories from birth to adulthood (2019, positive): “The ability to quantify inborn susceptibility using GPSs is likely to be generalizable across a broad range of complex diseases, contingent upon availability of a large discovery GWAS, independent validation and testing datasets, and the heritability of a given disease explained by common variants (”