Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature
By Xingjun Zhu, Wei Feng, Jian Chang, Yan-Wen Tan, Jiachang Li, Min Chen, Yun Sun, Fuyou Li. Nature Communications, 2016
867 citations recorded by the source corpus.
Photothermal therapy (PTT) at present, following the temperature definition for conventional thermal therapy, usually keeps the temperature of lesions at 42–45 °C or even higher. Such high temperature kills cancer cells but also increases the damage of normal tissues near lesions through heat conduction and thus brings about more side effects and inhibits therapeutic accuracy. Here we use temperature-feedback upconversion nanoparticle combined with photothermal material for real-time monitoring of microscopic temperature in PTT. We observe that microscopic temperature of photothermal material upon illumination is high enough to kill cancer cells when the temperature of lesions is still low enough to prevent damage to normal tissue. On the basis of the above phenomenon, we further realize high spatial resolution photothermal ablation of labelled tumour with minimal damage to normal tissues in vivo. Our work points to a method for investigating photothermal properties at nanoscale, and for the development of new generation of PTT strategy. In photothermal therapy for cancer treatment, hyperthermic effects can damage healthy tissues and inhibit therapeutic efficacy. Here, the authors use core-shell lanthanide-based nanoparticles to monitor microscopic temperatures and to ablate cancer tissue at low temperatures.
Subfields: Biomedical Engineering, Electronic, Optical and Magnetic Materials
View Paper: https://www.semanticscholar.org/paper/a6948dc95996d176060d644f015a01c1a8184e26
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In Biomedical Engineering
In Electronic, Optical and Magnetic Materials
Citations in the corpus
- Losses in plasmonics: from mitigating energy dissipation to embracing loss-enabled functionalities (2017, background): “Temperature-feedback luminescent materials combined with plasmonic nanoparticles already find use in real-time monitoring of microscopic temperature to avoid causing damage to surrounding benign cells during photothermal therapy [170,189,199,194].”