Targeting DNA topoisomerase II in cancer chemotherapy

By J. Nitiss. Nature Reviews. Cancer, 2009

1,699 citations recorded by the source corpus.

Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. Although the biological functions of TOP2 are important for ensuring genomic integrity, the ability to interfere with TOP2 and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. The molecular tools that have allowed an understanding of the biological functions of TOP2 are also being applied to understanding the details of drug action. These studies promise refined targeting of TOP2 as an effective anticancer strategy.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a673d109b1fbd5ad35d1705401bc1c555a8c5ac2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

Doxorubicin, DNA torsion, and chromatin dynamics (2013, positive): “Doxorubicin has been hypothesized to function in a similar way [15] and it has been shown that topoisomerase II levels determine the effectiveness of doxorubicin treatment in a mouse model of lymphoma [16].”
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability (2016, neutral): “Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.”
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs (2010, neutral): “Top2 Catalytic Cycle Top2 a and b function as homodimers and require Mg 2+ (Figures 4C and 5A) (for more details, see Deweese et al., 2009; Nitiss, 2009b; Schoefﬂer and Berger, 2008; Wang, 2009a).”