Apoptosis and necrosis: detection, discrimination and phagocytosis.

By D. Krysko, T. Vanden Berghe, K. D’Herde, Peter Vandenabeele. Methods, 2008

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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014, background): “Second, the negative morphologic definition of necrosis as a cell death modality that fails to exhibit apoptotic or autophagic features has been reconsidered.(22,74) Indeed, necrosis can manifest with a stereotyped panel of features, including a generalized swelling of the cytoplasm, which acquires ”
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death (2017, unknown): “An additional feature of secondary necrosis is the release of active caspase-3 p17 fragment in the culture supernatant 40,41 .”