Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
By Junying Yuan, Palak Amin, D. Ofengeim. Nature Reviews Neuroscience, 2018
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Apoptosis is crucial for the normal development of the nervous system, whereas neurons in the adult CNS are relatively resistant to this form of cell death. However, under pathological conditions, upregulation of death receptor family ligands, such as tumour necrosis factor (TNF), can sensitize cells in the CNS to apoptosis and a form of regulated necrotic cell death known as necroptosis that is mediated by receptor-interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL). Necroptosis promotes further cell death and neuroinflammation in the pathogenesis of several neurodegenerative diseases, including multiple sclerosis, amyotrophic lateral sclerosis, Parkinson disease and Alzheimer disease. In this Review, we outline the evidence implicating necroptosis in these neurological diseases and suggest that targeting RIPK1 might help to inhibit multiple cell death pathways and ameliorate neuroinflammation. Necroptosis is a form of cell death mediated by receptor-interacting protein kinase 1 (RIPK1), and is observed in several CNS disorders. Here, Yuan, Amin and Ofengeim give an overview of necroptosis in the CNS and explain its relationship with inflammation in CNS disorders.
Subfields: Molecular Biology, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/a6626d511f6ce29e1ffd0f9740b5c693cadb4fb3
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In Molecular Biology
Citations in the corpus
- ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019, background): “…of inflammatory diseases (Ikeda et al., 2011; Matmati et al., 2011; Tokunaga et al., 2011; Vince et al., 2012; Kumari et al., 2014; Rickard et al., 2014; Vande Walle et al., 2014; Gurung et al., 2015; Xu et al., 2018; Peltzer and Walczak, 2019; Polykratis et al., 2019; Yuan et al., 2019).”