The distribution and function of phosphatidylserine in cellular membranes.

By Peter A. Leventis, S. Grinstein. Annual Review of Biophysics, 2010

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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer (2016, background): “asymmetric distribution of phospholipids across their bilayer membrane, where the choline-containing phospholipids, phosphatidylcholine (PC) and sphingomyelin are predominately maintained on the outer membrane leaflet, and the amino-phospholipids (phosphatidylserine (PS) and phosphatidylethanolamine”
Piezos are pore-forming subunits of mechanically activated channels (2012, background): “In the first configuration, MmPiezo1 was reconstituted into asymmetric bilayers that mimic the cellular environment: the extracellular-facing lipid monolayer is predominantly neutral whereas the intracellular-facing leaflet is negatively charge”
Lipid map of the mammalian cell (2011, background): “This possibly drives the budding of transport vesicles in post-Golgi vesicle trafficking (Leventis and Grinstein, 2010).”
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013, neutral): “regulated by aminophospholipid translocases [62–64], proteins that transfer phospholipids from one leaflet of the”
An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. (2015, background): “The first category of flippases comprises a family of proteins that translocate specific phospholipids from the inner to outer leaflets in an ATP-dependent manner [3,102].”