DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

By J. A. Williams, R. Hyland, Barry C. Jones, Dennis A. Smith, Susan I. Hurst, T. Goosen, Vincent C. Peterkin, Jeffrey R. Koup, S. Ball. Drug Metabolism And Disposition, 2004

927 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/a5f30956501b9ee5b4d667055255196cb67774ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. A. Rowland
2. J. Miners
3. P. Mackenzie

Citations in the corpus

• The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification. (2013, background): “In vitro experiments have identified a large number of drugs that have the capacity to inhibit UGTs; however in many cases these interactions fail to translate to clinically relevant DDIs and adverse drug reactions (ADRs) (Williams et al., 2004; Miners et al., 2010b).”