Normal ranges of heart rate and respiratory rate in children from birth to 18 years: a systematic review of observational studies

By S. Fleming, Matthew J. Thompson, R. Stevens, C. Heneghan, D. Mant. The Lancet, 2011

1,167 citations recorded by the source corpus.

Summary Background Although heart rate and respiratory rate are routinely measured in children in acute settings, current reference ranges are not evidence-based. The aim of this study is to derive new centile charts for heart rate and respiratory rate using systematic review data from existing studies, and to compare these with existing international ranges. Methods We searched MEDLINE, EMBASE, and CINAHL to April 2009, and reference lists to identify studies which had measured heart rate and/or respiratory rate in normal children between birth and 18 years of age. We used a non-parametric kernel regression method to create centile charts for heart rate and respiratory rate with respect to age. We compared existing reference ranges with those derived from the centile charts. Findings We included 69 studies, 59 of which provided data on the heart rate of 143,346 children, and 20 on the respiratory rate of 3,881 children. Our new centile charts demonstrate the decline in respiratory rate from birth to early adolescence, with the steepest decline apparent in infants under two years; decreasing from a median of 44 breaths/minutes at birth to 26 breaths/minute at the age of two. The heart rate centile chart demonstrates a small peak at one month of age. The median heart rate increases from 127 beats/minute at birth to a maximum of 145 beats/minute at approximately one month of age, before decreasing to 113 beats/minute by the age of two. Comparison of the centile charts with existing published reference ranges for heart rate and respiratory rate show marked disagreement with the centile charts, with limits from published ranges frequently exceeding the 99th and 1st centiles, or crossing the median. Interpretation Our review shows that existing international guidelines for heart rate and respiratory rate in children are not based on evidence. We have created new centile charts based on a systematic review of studies which have measured these vital signs in normal children. Clinical and resuscitation guidelines should be updated in the light of these evidence-based reference ranges. Funding Research funded by the National Institute for Health Research programme grant for applied research ‘Development and implementation of new diagnostic processes and technologies in primary care’. SF was funded by the Engineering and Physical Sciences Research Council and the National Institute for Health Research Biomedical Research Centre Programme.

Subfields: Biomedical Engineering, Cardiology and Cardiovascular Medicine

View Paper: https://www.semanticscholar.org/paper/a5c8cd8c663bce04786497b87a38ebac7007102b

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Citations in the corpus

Breathing Rate Estimation From the Electrocardiogram and Photoplethysmogram: A Review (2017, neutral): “Furthermore, it may need to be adjusted according to the patient population, particularly for children [230].”
The Importance of Respiratory Rate Monitoring: From Healthcare to Sport and Exercise (2020, background): “Normal f R values (eupnea) range from 12 breaths/min to 20 breaths/min in adults [30], while the normal values for children vary according to age [31].”
Modeling Missing Data in Clinical Time Series with RNNs (2016, methodology): “Additionally, we correct for differences in heart rate, respiratory rate, (Fleming et al., 2011) and blood pressure (NHBPEP Working Group 2004) due to age and gender using tables of normal values from large population studies.”
Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis (2014, background): “22 – 25 In hospitalized children, the 50th percentile for respiratory rate decreased from 41 at 0 to 3 months of age to 31 at 12 to 18 months of age.”
Directly Modeling Missing Data in Sequences with RNNs: Improved Classification of Clinical Time Series (2016, methodology): “Additionally, we correct for differences in heart rate, respiratory rate, (Fleming et al., 2011) and blood pressure (NHBPEP Working Group 2004) due to age and gender using tables of normal values from large population studies.”