Bactericidal Effect of Zero-Valent Iron Nanoparticles on Escherichia coli

By Changha Lee, J. Kim, Wonil Lee, K. Nelson, Jeyong Yoon, D. Sedlak. Environmental Science and Technology, 2008

752 citations recorded by the source corpus.

Zero-valent iron nanoparticles (nano-Fe0) in aqueous solution rapidly inactivated Escherichia coli (E. coli). A strong bactericidal effect of nano-Fe0 was found under deaerated conditions, with a linear correlation between log inactivation and nano-Fe0 dose (0.82 log inactivation / mg/L nano-Fe0 · hr). The inactivation of E. coli under air saturation required much higher nano-Fe0 doses due to the corrosion and surface oxidation of nano-Fe0 by dissolved oxygen. Significant physical disruption of the cell membranes was observed in E. coli exposed to nano-Fe0, which may have caused the inactivation, or enhanced the biocidal effects of dissolved iron. The reaction of Fe(II) with intracellular oxygen or hydrogen peroxide also may have induced oxidative stress by producing reactive oxygen species. The bactericidal effect of nano-Fe0 was a unique property of nano-Fe0, which was not observed in other types of iron-based compounds.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/a5c01bb4489ebb954d5df4495fcc6c513608e128

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In Biomedical Engineering

1. S. Tang
2. I. Lo
3. Teresa A. P. Rocha-Santos

In Materials Chemistry

1. S. Tang
2. A. Azzam
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4. B. Amin
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7. Teresa A. P. Rocha-Santos

Citations in the corpus

• Mycosynthesis of iron nanoparticles by Alternaria alternata and its antibacterial activity (2015, background): “When FeNPs penetrate cells through disrupted membranes, it causes further physical damage and death (Lee et al., 2008).”
• Synthesis of Fe3O4 nanoparticles and its antibacterial application (2015, background): “[40] stated that the iron nanoparticles caused the inactivation of E.”
• Magnetic nanoparticles: essential factors for sustainable environmental applications. (2013, background): “The decrease of bactericidal effects of oxidized nZVI and nZVI under aerobic condition indicated that the key role of chemical reactivity of nZVI (Lee et al., 2008; Li et al., 2010a,b).”