Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells.

By Feng Wang, Yu-Cai Wang, Shuang Dou, Menghua Xiong, Tian-meng Sun, Jun Wang. ACS Nano, 2011

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Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer (2018, background): “Another drug, doxorubicin (DOX), when bound to gold nanoparticles via an acid labile linker, showed enhanced toxicity against the multi drug resistant MCF-7/ADR breast cancer cell line, thus overcoming the multi drug resistance to some extent due to the enhanced uptake of the gold nanoparticle-tethe”
Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine (2019, methodology): “Doxorubicin (DOX) was attached to Au NPs, through a pH-sensitive linker, in order to provide an efficient intracellular triggered DOX release (inside acidic organelles), thereby enhancing therapeutic effects in drug-resistant tumor cells [133].”
The Smart Drug Delivery System and Its Clinical Potential (2016, background): “In addition, gold nanoparticles (AuNPs) have widely been explored for photothermal therapy (PTT) in the biomedical field [149-154].”
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine. (2019, neutral): “rubicin to multidrug resistant cancer cells [206].”