A theory of biological relativity: no privileged level of causation

By Denis Noble. Interface Focus, 2012

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A Manifesto for a Processual Philosophy of Biology (2018, background): “While much progress has been made in understanding wholes, such as cells, in terms of their organelles, macromolecules, and other subcellular assemblies, a consensus is emerging that understanding these entities cannot be fully accomplished without essential reference to the systems of which they ar”
Gene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effort (2013, background): “Thus, the DbTFs are a point of convergence for mechanisms involved in upward causation, i.e. the flow of information from genome to phenome (central dogma), as well as in downward causation, which enables the organism to respond to cues from the extrinsic and intrinsic environment (9).”
Everything Flows : Towards a Processual Philosophy of Biology (2018, background): “…wholes such as cells in terms of their organelles, macromolecules, and other subcellular assemblies, a consensus is emerging that understanding these entities cannot be fully accomplished without a vital reference to the systems of which they are parts (e.g. Boogerd et al. 2007; Noble 2012).”
Neuroscience Needs Behavior: Correcting a Reductionist Bias. (2017, neutral): “Take, for example, the cardiac rhythm—a behavior that is the net consequence of the interplay between a cell’s membrane and the ion channels in it (Noble, 2012).”