CD107a as a functional marker for the identification of natural killer cell activity.

By G. Alter, Jessica M Malenfant, M. Altfeld. JIM - Journal of Immunological Methods, 2004

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Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10 (2009, methodology): “For the measuring of granule exocytosis by CD107a, we added fluorescence-labeled CD107a-specific mAb or isotype control mAb (BD Biosciences) to the in vitro stimulation cultures and measured the surface accumulation of CD107a by flow cytometr”
The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, methodology): “The expression of LAMP-1 on NK cell surface has been used as an indirect measurement of NK cells cytolytic function (83).”
Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “CD107a is a lysosomal membrane protein that colocalizes with perforin in secretory lysosomes and redistributes to the cell surface when granules fuse with the plasma membrane (112, 139).”