Endometriosis and Infertility: A review of the pathogenesis and treatment of endometriosis-associated infertility

By M. Macer, H. Taylor. Obstetrics and Gynecology Clinics of North America, 2012

657 citations recorded by the source corpus.

Synopsis Endometriois has been associated with infertility, however the mechanism by which it affects fertility are still not fully understood. This manuscript reviews the proposed mechanisms of endometriosis pathogenesis, it affects on fertility and treatments of endometriosis-associated infertility. Theories on etiology of disease include retrograde menstruation, coelomic metaplasia, altered immunity, stem cells, and genetics. Endometriosis affects gametes and embryos, the fallopian tubes and embryo transport, and the eutopic endometrium; these abnormalities likely all impact fertility. Current treatment options of endometriosis-associated infertility include surgery, superovulation with IUI, and IVF. We also discuss potential future treatments for endometriosis related infertility such as stem cells transplantation and immune therapy.

Subfields: Immunology, Obstetrics and Gynecology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/a4c4754321cb104185f44dcc6c7c191f838a3993

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1. Krina T. Zondervan
2. C. Becker
3. S. Missmer
4. K. Koga
5. Robert N. Taylor
6. P. Viganò

Citations in the corpus

• Endometriosis (2018, background): “GnRH is a hormone [25] that the hypothalamus in the brain produces and sends to the pituitary gland [26], which signals the ovaries to produce estrogen [22] that controls the menstrual cycle.”