Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.

By T. Gide, Camelia Quek, A. Menzies, Annie Tasker, Ping Shang, Jeff Holst, J. Madore, S. Lim, R. Velickovic, M. Wongchenko and 15 more. Cancer Cell, 2019

899 citations recorded by the source corpus.

Cancer immunotherapies provide survival benefits in responding patients, but many patients fail to respond. Identifying the biology of treatment response and resistance are a priority to optimize drug selection and improve patient outcomes. We performed transcriptomic and immune profiling on 158 tumor biopsies from melanoma patients treated with anti-PD-1 monotherapy (n = 63) or combined anti-PD-1 and anti-CTLA-4 (n = 57). These data identified activated T cell signatures and T cell populations in responders to both treatments. Further mass cytometry analysis identified an EOMES+CD69+CD45RO+ effector memory T cell phenotype that was significantly more abundant in responders to combined immunotherapy compared with non-responders (n = 18). The gene expression profile of this population was associated with longer progression-free survival in patients treated with single agent and greater tumor shrinkage in both treatments.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/a4713077a7dcd3ed9f3f6aa9ebaeacf118848d6f

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In Immunology

1. W. Zou
2. Ilona Kryczek
3. Shuang Wei
4. Lieping Chen
5. D. Pardoll

In Oncology

1. W. Zou
2. Lieping Chen

Citations in the corpus

• Tumor-infiltrating lymphocytes in the immunotherapy era (2020, neutral): “In addition, there was an abundance of TRM cells in ICB responders.(192) Complementary research has demonstrated an increased prevalence of TRM cells in treatmentnaive tumors versus healthy adjacent tissue, as well as demonstrating that ICB responders are characterized by CD8 TCM cell accumulation.”
• CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 (2022, positive): “Data and code availability— Lipidomic raw data and files have been deposited to Mendeley: doi:10.17632/kvp23k439m.1 Gene expression profiles of human cancer tissues were from GSE100797 (Lauss et al., 2017) and PRJEB23709 (Gide et al., 2019).”