Print Me An Organ! Why We Are Not There Yet

By Wei Long Ng, C. K. Chua, Yu-Fang Shen. Progress in polymer science, 2019

287 citations recorded by the source corpus.

Abstract Bioprinting offers a highly-automated and advanced manufacturing platform that facilitates the deposition of bio-inks (living cells, biomaterials and growth factors) in a scalable and reproducible manner, a process that is lacking in conventional tissue engineering approaches. Significant improvements in the field of bioprinting have occurred over the last two decades. This reviews provides an in-depth analysis of recent improvements in the bioprinting techniques, progress in bio-ink development, implementation of new bioprinting and tissue maturation strategies. Special attention is givent to the role of polymer science and how it complements 3D bioprinting to overcome some of the major impediments in the field of organ printing. A concise overview of the anatomy and physiology of different tissues/organs is provided, followed by important design considerations to better facilitate the fabrication of biomimetic tissues/organs for tissue engineering and regenerative medicine (TERM). Last, a realistic overview of current status in organ bioprinting is presented, including recent accomplishments in bioprinting tissue-engineered constructs, the limitations and challenges, as well as opportunities for future research. We strongly believe that with the advances in polymer sciences, it will be an impending reality for on-demand bioprinting of patient-specific tissues/organs.

Subfields: Automotive Engineering, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a46fa4c2f3aa262a570c1e1cb19e23ba32d6e700

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In Automotive Engineering

1. Kun Zhou
2. J. An
3. Wenjing Yang
4. C. K. Chua

In Biomedical Engineering

1. J. An
2. Kun Zhou
3. Wenjing Yang
4. C. K. Chua

Citations in the corpus

• Acoustic absorptions of multifunctional polymeric cellular structures based on triply periodic minimal surfaces fabricated by stereolithography (2020, methodology): “…through layer-by-layer buildup of pre-designed computer models (An et al. 2015; Zhuang et al. 2018; Yuan, Chua, and Zhou 2019a; Lee et al. 2016a; Ng, Chua, and Shen 2019; An, Chua, and Mironov 2016; Sing et al. 2015; Lee, An, and Chua 2017b, 2017a; Yuan et al. 2019b; Low et al. 2001; Cheah et…”