Targeting tumor-associated macrophages to synergize tumor immunotherapy
By Xiaonan Xiang, Jianguo Wang, D. Lu, Xiao Xu. Signal Transduction and Targeted Therapy, 2021
844 citations recorded by the source corpus.
The current treatment strategies in advanced malignancies remain limited. Notably, immunotherapies have raised hope for a successful control of these advanced diseases, but their therapeutic responses are suboptimal and vary considerably among individuals. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment (TME) and are often correlated with poor prognosis and therapy resistance, including immunotherapies. Thus, a deeper understanding of the complex roles of TAMs in immunotherapy regulation could provide new insight into the TME. Furthermore, targeting of TAMs is an emerging field of interest due to the hope that these strategies will synergize with current immunotherapies. In this review, we summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies, and discuss the therapeutic potential of targeting TAMs as an adjuvant therapy in tumor immunotherapies.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/a464b7b71db95ff76520f61eceb31465a72fb2ee
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Citations in the corpus
- Macrophages in immunoregulation and therapeutics (2023, background): “Therefore, macrophage-targeted therapy is emerging, and some have been translated into clinical trials.(367,399) Several immunotherapeutic approaches may benefit from macrophage depletion, such as CCL2 vaccination [406] and ICIs such as PD-1 and CTLA4 [407–409].”
- Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “227 Dysregulation of the mTOR pathway has been implicated in the polarization and function of macrophages.”