Turning cold tumors into hot tumors to ignite immunotherapy

By Yuan Liu, Yun-Long Wang, Shuo Wang, Jia‐Jun Li, Wei He, Xin-Juan Fan, Xiang-Bo Wan. 2025

Subfields: Cancer Research, Immunology, Oncology

Citations in the corpus

• TROP2 expression in head and neck squamous cell carcinoma: association with the tumor immune microenvironment and clinical outcome (2026, unknown): “Such dynamic changes in immune composition have been reported in advanced HNSCC, where tumors may shift toward more immunologically “ cold ” phenotypes characterized by reduced T-cell in fi ltration and increased immunosuppressive signaling (47 – 49).”