Structural Basis of Heteromeric Smad Protein Assembly in TGF-β Signaling

By B. Chacko, B. Qin, A. Tiwari, G. Shi, S. Lam, Lawrence J. Hayward, M. D. de Caestecker, Kai Lin. 2004

189 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a441c675e333f9ca7336a495e9172abf6de359fb

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In Molecular Biology

1. J. Massagué
2. J. Seoane
3. R. Derynck
4. D. Wotton
5. Xin-Hua Feng
6. A. Moustakas
7. C. Heldin
8. Nikolaos G. Frangogiannis

Citations in the corpus

• Smad transcription factors. (2005, background): “Domain mapping studies (Zhang et al. 1996; Hata et al. 1997), and later structural data (Shi et al. 1997; Chacko et al. 2004), demonstrated that the MH2 domains in response to TGF or BMP stimulation form a complex with transcriptional activation potential.”
• SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS (2005, background): “ARC105, a component of this complex, is recruited to the Smad-responsive promoter in response to activin/nodal and binds Smad2/3 and Smad4, but not Smad1, in response to TGF-β (Kato et al. 2002).”