Modes of cancer cell invasion and the role of the microenvironment.
By Andrew G. Clark, D. Vignjevic. Current Opinion in Cell Biology, 2015
718 citations recorded by the source corpus.
Metastasis begins with the invasion of tumor cells into the stroma and migration toward the blood stream. Human pathology studies suggest that tumor cells invade collectively as strands, cords and clusters of cells into the stroma, which is dramatically reorganized during cancer progression. Cancer cells in intravital mouse models and in vitro display many 'modes' of migration, from single isolated cells with round or elongated phenotypes to loosely-/non-adherent 'streams' of cells or collective migration of cell strands and sheets. The tumor microenvironment, and in particular stroma organization, influences the mode and dynamics of invasion. Future studies will clarify how the combination of stromal network structure, tumor cell signaling and extracellular signaling cues influence cancer cell migration and metastasis.
Subfields: Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/a43996d2f778018162cdc0f8ea1b56c7236d239c
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Citations in the corpus
- Revisiting the hallmarks of cancer. (2017, neutral): “Although most human carcinoma cells migrate collectively, most cells in in vivo and in vitro studies migrate individually; this could be related to the TME evolving alongside the former group [105].”
- The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “The master cell guides cells that maintain intercellular junctions to migrate in narrow lines, clusters, or broadsheets, and the phenotype of the cells is influenced differently by the following cells [164, 165].”
- Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer (2017, background): “First, IHC analyses clearly showed that the program localizes to the leading edge of primary tumors, potentially enabling the collective migration of cohorts of cells (Figure 7E) (Clark and Vignjevic, 2015; Lambert 171, 1611–1624, December 14, 2017 1621 et al., 2017).”