Lung Cancer Risk after Exposure to Polycyclic Aromatic Hydrocarbons: A Review and Meta-Analysis
By Ben Armstrong, E. Hutchinson, J. Unwin, T. Fletcher. Environmental Health Perspectives, 2004
610 citations recorded by the source corpus.
Typical polycyclic aromatic hydrocarbon mixtures are established lung carcinogens, but the quantitative exposure–response relationship is less clear. To clarify this relationship we conducted a review and meta-analysis of published reports of occupational epidemiologic studies. Thirty-nine cohorts were included. The average estimated unit relative risk (URR) at 100 μg/m3 years benzo[a]pyrene was 1.20 [95% confidence interval (CI), 1.11–1.29] and was not sensitive to particular studies or analytic methods. However, the URR varied by industry. The estimated means in coke ovens, gasworks, and aluminum production works were similar (1.15–1.17). Average URRs in other industries were higher but imprecisely estimated, with those for asphalt (17.5; CI, 4.21–72.78) and chimney sweeps (16.2; CI, 1.64–160.7) significantly higher than the three above. There was no statistically significant variation of URRs within industry or in relation to study design (including whether adjusted for smoking), or source of exposure information. Limited information on total dust exposure did not suggest that dust exposure was an important confounder or modified the effect. These results provide a more secure basis for risk assessment than was previously available.
Subfields: Health, Toxicology and Mutagenesis, Pulmonary and Respiratory Medicine, Speech and Hearing
View Paper: https://www.semanticscholar.org/paper/a4141c9f2bbf6effdbbc3388b918929928d8a263
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Citations in the corpus
- Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide (2007, background): “Two review articles have been published on epidemiological studies in which the relationship between exposure to PAH and lung and bladder cancers in occupationally exposed subjects was investigated ( Armstrong et al, 2004 ; Mastrangelo et al, 1996 ).”
- Health risk assessment on human exposed to environmental polycyclic aromatic hydrocarbons pollution sources. (2006, background): “The relationship between cancer and the environment is largely conditioned by investigations involving PAH exposures (Armstrong et al., 2004).”
- A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. (2013, background): “The most potent PAH carcinogens have been identified to include benzo[a] anthracene, benzo[a]pyrene, and dibenz[ah]anthracene (Armstrong et al., 2004; Bach et al., 2003; CCME, 2010).”