Evolution of the cancer genome
By L. Yates, Peter J. Campbell. Nature reviews genetics, 2012
657 citations recorded by the source corpus.
The advent of massively parallel sequencing technologies has allowed the characterization of cancer genomes at an unprecedented resolution. Investigation of the mutational landscape of tumours is providing new insights into cancer genome evolution, laying bare the interplay of somatic mutation, adaptation of clones to their environment and natural selection. These studies have demonstrated the extent of the heterogeneity of cancer genomes, have allowed inferences to be made about the forces that act on nascent cancer clones as they evolve and have shown insight into the mutational processes that generate genetic variation. Here we review our emerging understanding of the dynamic evolution of the cancer genome and of the implications for basic cancer biology and the development of antitumour therapy.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a3f6fb0069ce14102449b8ba126afc9b7d0d31b2
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In Cancer Research
In Molecular Biology
Citations in the corpus
- Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. (2015, background): “Accumulating evidence suggests that not every mutation, whether driver or passenger, will be found in every cancer cell within a tumor (see reviews Swanton, 2012; Yates and Campbell, 2012).”
- Cancer Evolution: Mathematical Models and Computational Inference (2014, background): “…Klein 2013; Junttila and de Sauvage 2013; Burrell et al. 2013; Meacham and Morrison 2013; Almendro et al. 2013; Aparicio and Caldas 2013; Greaves and Maley 2012; Marusyk et al. 2012; Caldas 2012; Podlaha et al. 2012; Lambert et al. 2011; Michor and Polyak 2010; Salk et al. 2010; Bowtell 2010).”
- Artificial intelligence in histopathology: enhancing cancer research and clinical oncology (2022, background): “alignant tumors are complex, heterogeneous, multicellular ecosystems 1–3 .”