Global increase and geographic convergence in antibiotic consumption between 2000 and 2015

By Eili Y. Klein, T. V. Van Boeckel, E. Martínez, Suraj Pant, Sumanth Gandra, Simon A. Levin, H. Goossens, Ramanan Laxminarayan. Proceedings of the National Academy of Sciences of the United States of America, 2018

2,750 citations recorded by the source corpus.

Significance Antibiotic resistance, driven by antibiotic consumption, is a growing global health threat. Our report on antibiotic use in 76 countries over 16 years provides an up-to-date comprehensive assessment of global trends in antibiotic consumption. We find that the antibiotic consumption rate in low- and middle-income countries (LMICs) has been converging to (and in some countries surpassing) levels typically observed in high-income countries. However, inequities in drug access persist, as many LMICs continue to be burdened with high rates of infectious disease-related mortality and low rates of antibiotic consumption. Our findings emphasize the need for global surveillance of antibiotic consumption to support policies to reduce antibiotic consumption and resistance while providing access to these lifesaving drugs. Tracking antibiotic consumption patterns over time and across countries could inform policies to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and enforcing per capita consumption targets or aiding investments in alternatives to antibiotics. In this study, we analyzed the trends and drivers of antibiotic consumption from 2000 to 2015 in 76 countries and projected total global antibiotic consumption through 2030. Between 2000 and 2015, antibiotic consumption, expressed in defined daily doses (DDD), increased 65% (21.1–34.8 billion DDDs), and the antibiotic consumption rate increased 39% (11.3–15.7 DDDs per 1,000 inhabitants per day). The increase was driven by low- and middle-income countries (LMICs), where rising consumption was correlated with gross domestic product per capita (GDPPC) growth (P = 0.004). In high-income countries (HICs), although overall consumption increased modestly, DDDs per 1,000 inhabitants per day fell 4%, and there was no correlation with GDPPC. Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxazolidinones, carbapenems, and polymyxins. Projections of global antibiotic consumption in 2030, assuming no policy changes, were up to 200% higher than the 42 billion DDDs estimated in 2015. Although antibiotic consumption rates in most LMICs remain lower than in HICs despite higher bacterial disease burden, consumption in LMICs is rapidly converging to rates similar to HICs. Reducing global consumption is critical for reducing the threat of antibiotic resistance, but reduction efforts must balance access limitations in LMICs and take account of local and global resistance patterns.

View Paper: https://www.semanticscholar.org/paper/a3f38113d49deedf49e72f81b733eb1dc0077a79

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Citations in the corpus

Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity (2019, background): “Leading consumers of antibiotics between low and middle-income countries were India, China, and Pakistan (Klein et al., 2018).”
Antibiotics as Major Disruptors of Gut Microbiota (2020, background): “Antibiotic use in childhood has been associated with several negative outcomes later in life, including the development of obesity, asthma, allergy, and IBD (Cho et al., 2012; Bokulich et al., 2016; Korpela et al., 2016; Turta and Rautava, 2016).”
Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “Despite this, antibiotics are still widely prescribed in disease treatment and studies have reported increased consumption of antibiotics in certain countries in the past number of years (Adriaenssens et al., 2011; Klein et al., 2018).”
Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy (2019, background): “Yet, the global use of antibiotics increased steadily over the past decades, both due to an augmentation of antibiotic use in human medicine and in other sectors of commercial activity [15].”