Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

By Yuanzeng Min, Kyle C. Roche, Shaomin Tian, M. Eblan, K. McKinnon, J. Caster, Shengjie Chai, Laura E. Herring, Longzhen Zhang, Tian Zhang and 5 more. Nature Nanotechnology, 2017

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Nanoparticles can be utilized to capture tumour antigens and improve their presentation, which in turn improves the efficacy of cancer immunotherapy. Immunotherapy holds tremendous promise for improving cancer treatment1. To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the ‘abscopal effect’2. Unfortunately, response rates for this strategy remain low3. Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC-NP formulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is dependent on the NP surface properties. We showed that AC-NPs deliver tumour-specific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of αPD-1 (anti-programmed cell death 1) treatment using the B16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC-NPs. Mechanistic studies revealed that AC-NPs induced an expansion of CD8+ cytotoxic T cells and increased both CD4+T/Treg and CD8+T/Treg ratios (Treg, regulatory T cells). Our work presents a novel strategy to improve cancer immunotherapy with nanotechnology.

Subfields: Biomedical Engineering, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/a3dda76f2dcbf68ba6cc08f4d3e7f9ab29ae29fb

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In Oncology

  1. Muyue Yang
  2. Xianqun Fan
  3. Jipeng Li
  4. P. Gu

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