Diabetes mellitus: The epidemic of the century.

By A. Kharroubi, H. Darwish. World Journal of Diabetes, 2015

1,107 citations recorded by the source corpus.

The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas, the Western Pacific region has the highest number of adults diagnosed with diabetes and has countries with the highest prevalence of diabetes (37.5%). Different classes of diabetes mellitus, type 1, type 2, gestational diabetes and other types of diabetes mellitus are compared in terms of diagnostic criteria, etiology and genetics. The molecular genetics of diabetes received extensive attention in recent years by many prominent investigators and research groups in the biomedical field. A large array of mutations and single nucleotide polymorphisms in genes that play a role in the various steps and pathways involved in glucose metabolism and the development, control and function of pancreatic cells at various levels are reviewed. The major advances in the molecular understanding of diabetes in relation to the different types of diabetes in comparison to the previous understanding in this field are briefly reviewed here. Despite the accumulation of extensive data at the molecular and cellular levels, the mechanism of diabetes development and complications are still not fully understood. Definitely, more extensive research is needed in this field that will eventually reflect on the ultimate objective to improve diagnoses, therapy and minimize the chance of chronic complications development.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics

View Paper: https://www.semanticscholar.org/paper/a264382d16dd559271e749456ae33aa710874d14

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Citations in the corpus

• Identification of genetic elements in metabolism by high-throughput mouse phenotyping (2018, neutral): “org/impress), we chose seven parameters: (1) basal blood glucose levels after overnight food deprivation (T0) and (2) the area under the curve (AUC) of glucose excursions during the intraperitoneal glucose tolerance test as a read out for glucosestimulated insulin secretion and insulin sensitivity (”
• Diabetes prediction using machine learning and explainable AI techniques (2022, background): “Diabetes is a chronic disease that directly affects the pancreas, and the body is incapable of producing insulin [22].”
• The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation (2020, background): “The disease affects primarily skeletal muscles and adipose tissue, but also liver, at the level of insulin receptors, the signal transduction system, and/or effector enzymes or genes [14].”