The origins of age-related proinflammatory state.

By Luigi Ferrucci, A. Corsi, F. Lauretani, Stefania Bandinelli, B. Bartali, Dennis D. Taub, J. Guralnik, Dan L. Longo. Blood, 2005

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We hypothesized that the rising levels of inflammatory markers with aging is explained by cardiovascular risk factors and morbidity becoming progressively more prevalent in older persons. Information on inflammatory markers, cardiovascular risk factors, and diseases was collected in 595 men and 748 women sampled from the general population (age, 20-102 years). In both men and women, older age was associated with higher levels of interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1ra), IL-18, C-reactive protein (CRP), and fibrinogen, while soluble IL-6 receptor (sIL-6r) increased significantly with age only in men. Adjusting for cardiovascular risk factors and morbidity, the age regression coefficients became substantially smaller in models predicting IL-6, IL-1ra, IL-18, and fibrinogen and larger in the model predicting sIL6r. Adjustment for cardiovascular morbidity substantially reduced the effect of age on CRP in men but not in women. Findings were confirmed in a subgroup of 51 men and 45 women with low risk profile and no cardiovascular morbidity. Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity.

Subfields: Epidemiology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/a258afe6c720748e473ea6183cd11b723a6571f6

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Citations in the corpus

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Tumor Necrosis Factor Alpha Another major player in the immune response is the proinflammatory cytokine TNF-α, which increases with age and is associated with age-related disease (196).”
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017, background): “As is the case for humans (Ferrucci et al., 2005), we expected strong biological variation in senescence and the SASP in naturally”
Measuring biological aging in humans: A quest (2019, background): “Interestingly, all of the “hallmarks of aging” cited above directly or indirectly cause an inflammatory state, suggesting that the pro-inflammatory state observed in many older persons may reflect the burden of biological aging (Ferrucci et al., 2005; Franceschi & Campisi, 2014; Fulop et al., 2018).”
Canonical Nlrp3 inflammasome links systemic low grade inflammation to functional decline in aging (2013, neutral): “…in multiple organs, including adipose tissue and CNS, is postulated to be a common mechanism leading to several chronic degenerative disorders that negatively impacts the healthspan of the elderly (Lumeng et al., 2011; Green et al., 2011; Ferrucci et al., 2005; Franceschi et al., 2007).”
Interleukin-6 in aging and chronic disease: a magnificent pathway. (2006, background): “1 pg/ml (women) in persons 85 years and older, and that the age trend is partially independent of major confounders (50).”