Classification and Epidemiology of MCI

By R. Roberts, David S. Knopman. Clinics in Geriatric Medicine, 2013

716 citations recorded by the source corpus.

Mild cognitive impairment (MCI) is an intermediate stage in the trajectory from normal cognition to dementia. Despite controversies about the classification of MCI, recent published criteria for MCI allow better comparison of the prevalence, incidence, and outcomes of MCI. Subjects with MCI have a high rate of progression to dementia over a relatively short period. Even among subjects who revert to normal cognition at one point in time, the rate of subsequent MCI or dementia is higher than among those who never develop MCI. Subjects with MCI also experience a greater mortality than cognitively normal subjects. Better characterization of MCI and understanding of the condition, may contribute to development of better diagnostic mechanisms including imaging and fluid biomarkers, and the development of therapeutic, and non-therapeutic interventions for MCI. In this review, we present an overview of the classification of MCI, estimates of the incidence and prevalence of MCI, risk factors for MCI, and the outcomes following an MCI diagnosis.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/a2248061f4d5d7b01fe10a98e982185984cb1590

Citations in the corpus

• Diagnosis of Early Alzheimer's Disease: Clinical Practice in 2021 (2021, neutral): “Typically, episodic memory, executive function, visuospatial function, and language are the most affected cognitive domains in the early stages of AD (29, 67, 68).”
• 2016 Alzheimer's disease facts and figures (2016, neutral): “Approximately 15 percent to 20 percent of people age 65 or older have MCI [22].”