Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease

By T. Heitzer, Titus Schlinzig, K. Krohn, T. Meinertz, T. Münzel. Circulation, 2001

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Endothelial dysfunction. (2004, background): “Noninvasive endothelial function testing predicted cardiovascular events in patients with coronary artery disease (55), peripheral artery disease (107), and hypertension (108) and in patients who underwent vascular surgery (109).”
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. (2003, background): “Postprandial oxidative stress is also associated with endothelial dysfunction, which has been suggested to be involved in the development of both hypertension and CVD.(46-48) All of these observations make a reduction in oxidative stress an interesting mechanism by which acarbose could mediate, at l”
Inflammation and insulin resistance. (2003, background): “5-year follow-up of 281 persons showing both ED and measures of oxidative stress to predict CVD events (8).”
Oxidative stress in end-stage renal disease: an emerging threat to patient outcome. (2003, background): “Indeed, ;90% of patients with forearm blood flow (FBF) above the median have been shown to remain event free for 7 years after the haemodynamic study, whilst fewer than a half of the patients with FBF below the median have a favourable course [44].”