One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?

By D. Tan, L. Manchester, M. Terrón, Luis J. Flores, R. Reiter. Journal of Pineal Research, 2007

1,595 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/a1b9f6af14c453ca11e14c678170446f1bcaf19c

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In Endocrine and Autonomic Systems

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Citations in the corpus

Melatonin: an ancient molecule that makes oxygen metabolically tolerable (2015, background): “This may also apply to animals where there is evidence that stress promotes elevated endogenous melatonin production [86, 87].”
Exogenous melatonin improves salt tolerance in tomato by regulating photosynthetic electron flux and the ascorbate–glutathione cycle (2019, background): “MT’s intermediate product, N1-acetyl-N2-formyl-5methoxykynuramine (AMFK), can scavenge ROS in a direct and efficient manner (Tan et al. 2007; Manchester et al. 2015).”
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK (2013, background): “The continuous protection exerted by melatonin and its metabolites, referred as the free radical scavenging cascade [19–21], makes melatonin highly effective, even at low concentrations, in protecting organisms from OS [21].”
Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection (2014, background): “Aiding in this cause are low-molecularweight (MW) endogenous antioxidants such as glutathione (GSH), ascorbate (Vitamin C), melatonin, lipoic acid, ubiquinone (Coenzyme Q10), and Vitamin E, which target water radiolysis products, partially oxidized biomolecules, and peroxynitrite (153, 282, 313, 325”
Melatonin membrane receptors in peripheral tissues: Distribution and functions (2012, neutral): “, 1979), and (3) the kynuric pathway that produces N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) (Hardeland et al., 1993; Hirata et al., 1974; Slominski et al., 2008; Tan et al., 2007).”
Melatonin in plants (2008, background): “Tan et al. (2007c) also investigated the potential relationships between MEL supplementation and environmental tolerance of plants.”
Alleviation of salinity stress on Vicia faba L. plants via seed priming with melatonin (2014, background): “One melatonin molecule may scavenge up to 10 free radicals (Tan et al., 2007), which contrasts with the classic antioxidants that typically detoxify one radical per molecule.”
Melatonin--a pleiotropic, orchestrating regulator molecule. (2011, background): “…of receptors and other binding sites indicates a remarkable pleiotropy of melatonin, which may potentially affect the majority of cells, in addition to other, receptor-independent chemical reactions such as free radical scavenging (Tan et al., 1993, 2007; Reiter, 1993a; Hardeland, 2005).”
Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate (2008, background): “Alpha-tocopherol helps to maintain homeostatic levels of ROS by terminating the chain reaction of oxidizing events [50].”