Vitamin B12 (cobalamin) deficiency in elderly patients
By E. Andrès, N. Loukili, E. Noel, G. Kaltenbach, Maher Ben Abdelgheni, A. Perrin, M. Noblet-Dick, F. Maloisel, J. Schlienger, J. Blicklé. Canadian Medical Association Journal, 2004
626 citations recorded by the source corpus.
VITAMIN B12 OR COBALAMIN DEFICIENCY occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%–20% of all cases), insufficent dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.
Subfields: Psychiatry and Mental health, Rheumatology, Surgery
View Paper: https://www.semanticscholar.org/paper/a1b9482157929ff2103be897acf5f64cbb495e2a
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Citations in the corpus
- The Human Gut Microbiome – A Potential Controller of Wellness and Disease (2018, background): “Deficiency of vitamins B5 and B12 have been linked to several disorders such as gastrointestinal discomfort, insomnia, neuropsychological and hematological disorders (Andres et al., 2004; Gominak, 2016).”
- Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes (2015, background): “A total of 63% of all the investigated genomes contained the NAD biosynthesis pathways.”