A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

By S. Dewire, D. Yamashita, D. Rominger, Guodong Liu, C. Cowan, T. Graczyk, Xiao-Tao Chen, P. Pitis, D. Gotchev, C. Yuan and 3 more. Journal of Pharmacology and Experimental Therapeutics, 2013

611 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a18dd0dcbd0c0d9c907bd864a06fc3ac2d766b40

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1. T. Gan

Citations in the corpus

• Poorly controlled postoperative pain: prevalence, consequences, and prevention (2017, background): “Oliceridine (TRV130) is a novel μ-receptor G-protein pathway-selective modulator that differentially activates G-protein coupling while limiting β-arrestin recruitment.(144,145) In Phase II clinical studies conducted in patients with moderate– severe acute pain after bunionectomy or abdominoplasty, ”