Suppression of body fat accumulation in myostatin-deficient mice.
By A. Mcpherron, Se-Jin Lee. Journal of Clinical Investigation, 2002
654 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/a131beb9ae19069489d54382866ea5c6a5a667fd
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In Endocrine and Autonomic Systems
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Citations in the corpus
- The Human Obesity Gene Map: The 2005 Update (2006, background): “2 GDF8 Growth differentiation factor 8, also known as myostatin Reduced adiposity and increased muscle mass Loss of Gdf8 expression also results in a significant reduction in adipose mass accumulation in agouti lethal yellow (A) and Lep mutants (383,384)”
- Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling (2011, background): “These studies, altogether, suggest an important role for TGF-b superfamily members in WAT and BAT biology, akin to the role of myostatin in muscle development (McPherron and Lee, 2002).”
- Exercise is the real polypill. (2013, background): “Although myostatin increases might contribute to insulin resistance (184, 360), obesity (185), muscle wasting (63, 70, 97, 154), or agingsarcopenia (523), its loss/inhibition decreases adiposity (164, 303, 521, 530), induces browning of the white adipose tissue [through AMPK-peroxisome proliferator-”
- Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis (2003, background): “Since decreased fat accumulation is observed both in knock-out mice that lack myostatin and in wild-type adult mice in which myostatin has been systemically administered (28, 38), it appears that myostatin may play distinct physiological roles during early development and during adult homeostatic pr”
- Myostatin negatively regulates satellite cell activation and self-renewal (2003, background): “persistent postnatal muscle growth and lack of muscle wasting observed in myostatin-null mice (McPherron and Lee, 2002).”