Evolving importance of kidney disease: from subspecialty to global health burden.

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Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. (2017, background): “Chronic kidney disease (CKD) is increasingly recognized as a global public health problem.(1) Kidney failure is the most severe form of CKD, and is fatal without treatment by renal replacement therapy (RRT; dialysis or kidney transplantation).”
Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality (2014, neutral): “CCF 17,102 31 6 (4-9) 290 1 1 (1) 1,746 3 1 (1)”
The Hippo signalling pathway and its implications in human health and diseases (2022, background): “Renal diseases have been recognized as a serious public health burden in the past decade.(312) Chronic kidney diseases have a widespread impact and have received much attention.”