CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.

By Niels Mailand, J. Diffley. 2005

366 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Johannes C. Walter
2. T. Halazonetis
3. Y. Fouad
4. C. Aanei

In Molecular Biology

1. Morgane Macheret
2. Johannes C. Walter
3. Masato T. Kanemaki
4. T. Halazonetis
5. Sachiko Muramatsu
6. Y. Fouad
7. C. Aanei

In Oncology

1. Morgane Macheret
2. Masato T. Kanemaki
3. T. Halazonetis
4. Y. Fouad
5. C. Aanei

Citations in the corpus

• In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, methodology): “S4C), all DONSON residues except those interacting with POLE2 (65-72) were deleted.”
• DNA replication stress as a hallmark of cancer. (2015, background): “Other oncogenes, such as RAS and MOS, which induce DNA replication stress, also enhance Cdc6 protein levels, and ectopic expression of Cdc6 is sufficient to induce DNA replication stress (63).”