Functional MT1 and MT2 melatonin receptors in mammals

By M. Dubocovich, M. Markowska. Endocrine, 2005

862 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Social Psychology

View Paper: https://www.semanticscholar.org/paper/a08795b1f9f044d7d7cc56a14ae6dc062724ca58

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In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

Citations in the corpus

Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions (2014, background): “In mammals, melatonin activates at least two high-affinity G protein-coupled receptors, the MT1 and MT2, which regulate a variety of cellular and physiological processes including neuronal firing, arterial vasoconstriction, cell proliferation, immune responses, and reproductive and metabolic functio”
Melatonin membrane receptors in peripheral tissues: Distribution and functions (2012, neutral): “MT1 receptors are expressed in the brain, cardiovascular system (including peripheral blood vessels, aorta and heart), immune system, testes, ovary, skin, liver, kidney, adrenal cortex, placenta, breast, retina, pancreas and spleen (Dubocovich and Markowska, 2005; Fischer et al., 2008b; Pandi-Peruma”
Melatonin--a pleiotropic, orchestrating regulator molecule. (2011, background): “MT1 leads to a pertussis toxin-sensitive vasoconstriction via opening of BKCa channels, whereas MT2 causes vasodilation (Mahle et al., 1997; Doolen et al., 1998; Régrigny et al., 1998; Dubocovich and Markowska, 2005; Hardeland and Poeggeler, 2007).”
A review of the molecular aspects of melatonin’s anti‐inflammatory actions: recent insights and new perspectives (2013, background): “Melatonin membrane receptors belong to the G protein-coupled receptor superfamily, and two functionally active sites have been cloned and characterized, that is, MT1 (Mel 1a) and MT2 (Mel 1b) [22].”
Melatonin: a multitasking molecule. (2010, background): “Although originally thought to have a rather limited distribution, with more advanced methodologies, these receptors have now been uncovered in virtually every organ and on many cells in all organisms (Dubocovich and Markowska, 2005).”
Melatonin and reactive oxygen and nitrogen species: a model for the plant redox network (2019, background): “In mammals, melatonin acts through its interaction with two types of receptors, MT1 and MT2 (70).”
Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “These effects are considered to be mediated by three specific melatonin-receptor subtypes, namely MT1, MT2, and the putative MT3 binding site (Barrenetxe et al., 2004; Dubocovich and Markowska, 2005).”