A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei

By Wolfgang M. Pauli, Amanda N. Nili, J. M. Tyszka. Scientific Data, 2017

487 citations recorded by the source corpus.

Recent advances in magnetic resonance imaging methods, including data acquisition, pre-processing and analysis, have benefited research on the contributions of subcortical brain nuclei to human cognition and behavior. At the same time, these developments have led to an increasing need for a high-resolution probabilistic in vivo anatomical atlas of subcortical nuclei. In order to address this need, we constructed high spatial resolution, three-dimensional templates, using high-accuracy diffeomorphic registration of T1- and T2- weighted structural images from 168 typical adults between 22 and 35 years old. In these templates, many tissue boundaries are clearly visible, which would otherwise be impossible to delineate in data from individual studies. The resulting delineations of subcortical nuclei complement current histology-based atlases. We further created a companion library of software tools for atlas development, to offer an open and evolving resource for the creation of a crowd-sourced in vivo probabilistic anatomical atlas of the human brain. Design Type(s) source-based data analysis objective • anatomical image analysis objective Measurement Type(s) anatomical structure Technology Type(s) probabilistic algorithm Factor Type(s) Image Weighting Type • regional part of brain Sample Characteristic(s) Homo sapiens • caudate nucleus • putamen • globus pallidus • subthalamic nucleus • substantia nigra pars reticulata • hypothalamus • habenular nucleus • ventral pallidum • nucleus accumbens • substantia nigra pars compacta • parabrachial pigmental nucleus • ventral tegmental area • amygdala • red nucleus • mammillary body Design Type(s) source-based data analysis objective • anatomical image analysis objective Measurement Type(s) anatomical structure Technology Type(s) probabilistic algorithm Factor Type(s) Image Weighting Type • regional part of brain Sample Characteristic(s) Homo sapiens • caudate nucleus • putamen • globus pallidus • subthalamic nucleus • substantia nigra pars reticulata • hypothalamus • habenular nucleus • ventral pallidum • nucleus accumbens • substantia nigra pars compacta • parabrachial pigmental nucleus • ventral tegmental area • amygdala • red nucleus • mammillary body Machine-accessible metadata file describing the reported data (ISA-Tab format)

Subfields: Biophysics, Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/a08167803324a2345479cff674f282dba748cf23

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In Radiology, Nuclear Medicine and Imaging

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  2. Marc Joliot

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