Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.

By Henry Markram, Joachim H. R. Lübke, M. Frotscher, Arnd Roth, Bert J. Sakmann. 1997

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Prefrontal Microcircuits: Membrane Properties and Excitatory Input of Local, Medium, and Wide Arbor Interneurons (2001, methodology): “This issue also has been addressed in other model systems such as the goldfish Mauthner cell (Korn et al., 1986), layer IV stellate (Feldmeyer et al., 1999), and layer V tufted pyramids of rat somatosensory cortex (Markram et al., 1997), but strong correlations were not observed.”
Dendritic excitability and synaptic plasticity. (2008, unknown): “Using voltage-sensitive dye imaging in neocortical neurons, Palmer and Stuart (583) estimated an average spine neck resistance of merely 170 M , implying only the very tail end of the distribution of synaptic conductances (493) would be sufficiently large to allow for a noticeable voltage drop DENDR”
Pyramidal cell communication within local networks in layer 2/3 of rat neocortex (2003, methodology): “In agreement with previous studies of local neuronal connectivity (Mason et al.1991; Markram et al.1997; Thomson & Deuchars, 1997; Gibson et al. 1999; Reyes & Sakmann, 1999; Thomson et al. 2002) we found low interpyramidal connectivity, in terms of both the number of unitary connections and the…”
Requirement of dendritic calcium spikes for induction of spike‐timing‐dependent synaptic plasticity (2006, methodology): “The classical view of STDP is that pairing a single AP with a single EPSP induces LTP at positive spike timings (EPSP before postsynaptic AP) and LTD at negative spike timings (EPSP after postsynaptic AP).”
Reinforcement learning with modulated spike timing dependent synaptic plasticity. (2007, background): “For example , induction of LTP at synapses connecting pairs of layer 5 pyramidal neurons requires higher frequency pairing (Ͼ10 Hz) in both visual (Sjöström et al. 2001) and somatosensory (Markram et al. 1997) cortices of rats, whereas Froemke and Dan (2002) could induce LTP with pairing at 0.2 Hz.”
Simulation of networks of spiking neurons: A review of tools and strategies (2006, unknown): “NCS development began in 1997, a time at which fascinating details of synaptic plasticity and connectivity were being discovered (Markram et al. 1997a,b) As of 2005, NCS developers achieved all the objectives above, using an ASCII ﬁle based command input ﬁle to deﬁne a hierarchy of reusable brain…”
Synaptic Basis of Cortical Persistent Activity: the Importance of NMDA Receptors to Working Memory (1999, background): “…contribute to synaptic transmission at intracortical connections of sensory cortices (Thomson et al., 1985; Larson-Prior et al., 1991; ArmstrongJames et al., 1993; Thomson and Deuchars, 1995; Markram et al., 1997) and frontal cortex (Sutor and Hablitz, 1989; Hirsch and Crépel, 1990; Kang, 1995).”
Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal Cortex (2015, background): “Are responses of L5b neurons to activation of L2SCs consistent with direct glutamatergic inputs? Light pulses evoked action potentials in L2SCs with short latency and synaptic potentials in L5b neurons with an additional delay of approximately 2 ms (Figures 4D and 4E), which is comparable to monosyn”
Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors. (2003, background): “38 Ϯ 0.06; p ϭ 0.59), suggesting tLTD At neocortical L5 connections, postsynaptic before premay act presynaptically to reduce glutamate release. synaptic spiking reliably produces LTD (Figures 1A and 1B; Markram et al., 1997b; Sjö strö m et al., 2001).”
Synaptic energy use and supply. (2012, unknown): “…for cortical pyramidal to interneuron synapses (Deuchars and Thomson, 1995), 4–6 for spiny stellate and pyramidal cell to pyramidal cell synapses in cortex (Markram et al., 1997; Silver et al., 2003), and 6 for excitatory synapses onto pyramidal cells in hippocampal area CA1 (Larkman et al., 1997).”