Dearomatization Strategies in the Synthesis of Complex Natural Products

By Stéphane P. Roche, J. Porco. Angewandte Chemie, 2011

969 citations recorded by the source corpus.

Evolution in the field of the total synthesis of natural products has led to exciting developments over the last decade. Numerous chemo-selective and enantioselective methodologies have emerged from total syntheses, resulting in efficient access to many important natural product targets. This Review highlights recent developments concerning dearomatization, a powerful strategy for the total synthesis of architecturally complex natural products wherein planar, aromatic scaffolds are converted to three-dimensional molecular architectures.

Subfields: Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/9ff7cd7829d082ee2a7326fe7d76f4461c6b9fde