Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function.

By B. Foley, S. Cooley, M. Verneris, Michelle Pitt, Julie M. Curtsinger, Xianghua Luo, S. López-Vergès, L. Lanier, D. Weisdorf, Jeffrey S. Miller. Blood, 2012

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The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “In human, memory NK cells respond to human CMV (HCMV) virus is known to express a high level of activating receptor NKG2C, and these NKG2C+ NK cells expand during acute infection as well as during secondary challenge (121).”
Pre-activation with IL-12, IL-15, and IL-18 induces CD25 and a functional high affinity IL-2 receptor on human cytokine-induced memory-like NK cells (2014, background): “These studies include cytomegalovirus reactivation after solid organ transplantation and HSCT, which may correlate with murine virus-induced memory NK cells [18,19].”
The broad spectrum of human natural killer cell diversity (2017, background): “…by flow cytometry within the pool of stage 4b Immunity 47, November 21, 2017 827 cells (CD34 CD117lo/ IL-1R1lo/ CD94/NKG2A+NKp80+CD16 CD57 ) (Freud and Caligiuri, 2006; Freud et al., 2016), suggesting that it is within this developmental stage (4b) that MHC class I-binding…”