Complex chronic comorbidities of COPD

By L. Fabbri, F. Luppi, B. Beghé, K. Rabe. European Respiratory Journal, 2008

703 citations recorded by the source corpus.

Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke. The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences. A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation. As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.

Subfields: Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/9f93e4c9f60265ae509c38291820d34d327ca8d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. D. Parums

In Pulmonary and Respiratory Medicine

1. D. Parums
2. P. Barnes
3. P. Calverley
4. Jorgen Vestbo
5. K. Rabe
6. A. Anzueto
7. R. Rodríguez-Roisín
8. C. Jenkins

Citations in the corpus

• Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. (2017, background): “Hypertension is likely to be the most frequently occurring comorbidity in COPD and may have implications for prognosis.(308,324)”
• Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. (2012, background): “Because the association with these other diseases seems to be stronger in patients with COPD than in patients without the disease (16), Fabbri and coworkers (31) proposed that perhaps COPD was just one more manifestation of a systemic inflammatory syndrome.”
• Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution (2023, positive): “Возможно, не которые характерные черты ХОБЛ, такие как системное воспаление, встречаются и при других заболеваниях, и в таком случае данный механизм позволяет объяснить связь между ХОБЛ и некоторыми сопутствующими за болеваниями [477].”
• Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. (2007, background): “Cardiovascular diseases are the most frequent and important disease coexisting with COPD (171, 172) and include four separate entities: ischemic heart disease, heart failure, atrial fibrillation, and hypertension.”