Li-Fraumeni syndrome

By Andrea González. Definitions, 2013

630 citations recorded by the source corpus.

The cancers most often associated with Li-Fraumeni syndrome include breast cancer, a form of bone cancer called osteosarcoma, and cancers of soft tissues (such as muscle) called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome.

Subfields: Oncology

View Paper: https://www.semanticscholar.org/paper/9f64444aaf62e9d80e4a3060b5194a04f9d3a136

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1. Pierre Fermey
2. É. Consolino
3. M. Gauthier-Villars
4. S. Baert-Desurmont
5. D. Stoppa-Lyonnet
6. B. Bressac-de Paillerets
7. M. Renaux-Petel
8. C. Bonaïti‐pellié

Citations in the corpus

• Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers. (2015, background): “Therefore, LFS can be defined as an inherited form of cancers caused by germline mutations of the TP53 gene.(6-9) Since its discovery, the French LFS working group has updated JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T”