The drug–target residence time model: a 10-year retrospective

By R. Copeland. Nature reviews. Drug discovery, 2015

665 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/9f4268ff181125639cf5f0dacbbfed0514da494a

How researchers see this paper

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In Molecular Biology

1. Ken A. Dill
2. Emiliano Brini
3. Carlos Simmerling
4. T. Croll

Citations in the corpus

• Protein storytelling through physics (2020, background): “The off-rate ( k off ) is a measure of the residence time that the ligand spends in the site and is sometimes a better predictor of biological efficacy than is the equilibrium binding affinity ( K = k on / k off ) ( 117 ).”