Cystic Fibrosis

By John McArdle1, Laurie Whittaker2. Journal of the Iowa Medical Society, 2009

8,078 citations recorded by the source corpus.

Subfields: Pediatrics, Perinatology and Child Health, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/9f231aa810ad53e821e12cd7aeb6f1e69a378211

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pediatrics, Perinatology and Child Health

1. P. Barnes
2. O. Strauß
3. B. K. Pedersen

In Pulmonary and Respiratory Medicine

1. Hans Clevers
2. P. Barnes
3. O. Strauß
4. B. K. Pedersen

Citations in the corpus

• Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. (2013, background): “, 1989), a disease that leads to the accumulation of viscous mucus in the pulmonary and gastrointestinal tract and to a current median life expectancy of approximately 40 years (Ratjen and Döring, 2003).”
• Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “GSH appears to play a major role in the etiology, progression , and potential treatment of cystic fibrosis, the most common hereditary disorder in Caucasian populations (Davies et al., 2007).”
• Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “Cystic fibrosis is a system disease, but the predominant symptom is progressive obstructive pulmonary disease, which over time leads to respiratory failure and respiratory heart disease (Davis et al., 1996).”
• RCSB Protein Data Bank: Enabling biomedical research and drug discovery (2019, background): “Inadequate chloride transport causes accumulation of mucus in lung and pancreas, leading to chronic pulmonary inflammation/infection and exocrine pancreatic insuffiency.(86) The most common disease-causing CFTR variants include deletion of Phe508, which accelerates protein degradation, and Arg117àHi”
• Diversity and significance of Burkholderia species occupying diverse ecological niches. (2003, background): “…723 © 2003 Society for Applied Microbiology and Blackwell Publishing Ltd, Environmental Microbiology, 5, 719–729 B. cepacia complex and CF Cystic fibrosis is the most frequent hereditary disease in Caucasian populations, affecting approximately 1 in 2570 live births (Rosenstein and Zeitlin, 1998).”