Cancer metabolism: fatty acid oxidation in the limelight

By Arkaitz Carracedo, Lewis C. Cantley, P. Pandolfi. Nature Reviews. Cancer, 2013

1,198 citations recorded by the source corpus.

Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment. However, the vast majority of the research into cancer metabolism has been limited to a handful of metabolic pathways, while other pathways have remained in the dark. This Progress article brings to light the important contribution of fatty acid oxidation to cancer cell function.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9ec45094433c316627a794899609c5ea23924c68

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Citations in the corpus

ROS homeostasis and metabolism: a dangerous liason in cancer cells (2016, background): “The PPP is a major catabolic pathway of glucose through which cancer cells produce large amounts of ribose-5 phosphate, a precursor of nucleotide synthesis and NADPH, a key molecule that is used to drive anabolic processes and to detoxify harmful ROS.90 Activation of the PPP represents a key hallmar”
Reprogramming of fatty acid metabolism in cancer (2019, background): “2).12,13 This is largely achieved through β-oxidation of stored lipids, leading to the production of acetyl-CoA through oxidative degradation of FAs.14,15 The acetylCoA produced from each round of β-oxidation can subsequently enter the tricarboxylic acid (TCA) cycle to generate NADH and FADH2 for th”
Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “fats, strongly influence the incidence of mammary and sigmoid colon cancers, through lipid peroxidation [116–119].”
The Warburg Effect: How Does it Benefit Cancer Cells? (2016, background): “Also, it is now widely accepted that mitochondria are key components of the biosynthetic program whose substrates in the tricarboxylic acid (TCA) cycle are used for nucleotide, amino acid, and lipid biosynthesis [39,40].”