Epigenetic reprogramming in cancer

By M. Suvà, Nicolò Riggi, Bradley E. Bernstein. Science, 2013

694 citations recorded by the source corpus.

The demonstration of induced pluripotency and direct lineage conversion has led to remarkable insights regarding the roles of transcription factors and chromatin regulators in mediating cell state transitions. Beyond its considerable implications for regenerative medicine, this body of work is highly relevant to multiple stages of oncogenesis, from the initial cellular transformation to the hierarchical organization of established malignancies. Here, we review conceptual parallels between the respective biological phenomena, highlighting important interrelationships among transcription factors, chromatin regulators, and preexisting epigenetic states. The shared mechanisms provide insights into oncogenic transformation, tumor heterogeneity, and cancer stem cell models.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9ec3e2d2a01182eb06f7ad9751b1bc5076d38b2a

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In Molecular Biology

1. Bradley E. Bernstein
2. William A. Flavahan
3. Elizabeth Gaskell
4. V. Schirrmacher

Citations in the corpus

• Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria (2017, background): “Disruption of numerous epigenetic proteins culminates in malignant disease (5); however, our understanding of the role of altered epigenome regulators in nonmalignant, immune-driven disorders is relatively limited.”
• Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells (2014, neutral): “…point to the importance of understanding the epigenetic identities and susceptibilities of such aggressive subpopulations (Binda et al., 2012; Day et al., 2013; Friedmann-Morvinski et al., 2012; Kim et al., 2013; Piccirillo et al., 2006; Singh et al., 2004; Son et al., 2009; Suva et al., 2013).”
• Epigenetic plasticity and the hallmarks of cancer (2017, background): “3 or its chaperone proteins that promote telomerase-independent telomere lengthening (57, 94), or by nongenetic mechanisms that simulate self-renewing stem cell states (9, 95).”
• Signal transduction in cancer. (2015, neutral): “Changes in the methylation state of promoters of genes that impact cancer can also play an important role in oncogenesis (Sandoval and Esteller 2012; Suva et al. 2013).”