X-ray structure of a protein-conducting channel

By B. Berg, W. Clemons, I. Collinson, Yorgo Modis, E. Hartmann, S. Harrison, Tom A. Rapoport. Nature, 2004

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. (2006, background): “This process is called ERAD (for ERassociated protein degradation), retrotranslocation, or dislocation (Meusser et al., 2005; Tsai et al., 2002 ), and it plays a role in many diseases.”
A structural model of the active ribosome-bound membrane protein insertase YidC (2014, background): “…nascent chains through its central aqueous channel (Cannon et al., 2005; Rapoport, 2007; Driessen and Nouwen, 2008) and insert TM domains through a lateral gate (Van den Berg et al., 2004; Gogala et al., 2014), our model suggests that the YidC substrates are inserted at the protein-lipid interface.”
The bacterial cell envelope. (2010, background): “This translocation reaction is catalyzed by an essential, heterotrimeric IM protein complex called SecYEG (Van den Berg et al. 2004).”
Multipass membrane protein structure prediction using Rosetta (2005, neutral): “It appears that TM helices emerge from the translocon as they are being translated on the ribosome soon after translocation into the membrane.(51) These preformed helices then assemble together in the membrane.”