COVID-19 cytokine storm: the interplay between inflammation and coagulation

By R. José, A. Manuel. The Lancet Respiratory Medicine, 2020

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Predictors of COVID-19 severity: A literature review (2020, background): “venous thromboembolisms that may lead to ventilation-perfusion mismatch.(54) Some investigators have proposed the use of D-dimer blood levels for patient triage.”
Aging in COVID-19: Vulnerability, immunity and intervention (2020, neutral): “virus may also play an important role in contributing to neuro− COVID and other systemic manifestations (Jose and Manuel, 2020; Wu and McGoogan, 2020).”
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes (2020, positive): “A direct correlation between systemic increases in pro-inflammatory cytokines and lung injury, multiple organ failure, and unfavorable prognosis in patients with severe COVID-19 has been suggested, and uncontrolled cytokine signaling can contribute to multi-organ damage (Jose and Manuel, 2020; Mehta”