Mutations in the DG Loop of Adenovirus Type 5 Fiber Knob Protein Abolish High-Affinity Binding to Its Cellular Receptor CAR

By I. Kirby, E. Davison, A. Beavil, C. Soh, T. Wickham, P. Roelvink, I. Kovesdi, B. Sutton, G. Santis. 1999

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Citations in the corpus

• Programmable protein delivery with a bacterial contractile injection system (2023, positive): “Notably, this activity was abolished when PVCs were equipped either with mutant Ad5 knob domains (Δ491/492—previ-ously shown to reduce binding of Ad5 to target cells 40 ; Extended Data Fig.”
• Update on adenovirus and its vectors. (2000, background): “Recent investigations have succeeded in defining the receptor-binding motif on the three-dimensional structure of the fibre head (Kirby et al., 1999 ; Santis et al., 1999) as well as on the CAR (Kirby et al.”