The Controlled Drug Delivery Systems: Past Forward and Future Back
By Kinam Park. Journal of Controlled Release, 2014
626 citations recorded by the source corpus.
The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms. Attention of the 2nd generation (1980-2010) was dedicated to development of zero-order release systems, self-regulated drug delivery systems, long-term depot formulations, and nanotechnology-based delivery systems. The latter part of the 2nd generation was consumed mostly for studying nanoparticle formulations. The Journal of Controlled Release (JCR) has played a pivotal role during the 2nd generation of drug delivery technologies, and it will continue playing a leading role for the next generation. Taking the right path towards the productive 3rd generation of drug delivery technologies requires honest open dialogues without any preconceived ideas of the past. The drug delivery field needs to take a bold approach of designing the future drug delivery formulations first, based on today’s necessities, and produce necessary innovations. The JCR will provide the forum for sharing the new ideas that will shape the 3rd generation of drug delivery technologies.
Subfields: Biomaterials, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/9df585a1b54e5db7602d92dca4b2223ac111d7ca
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In Pharmaceutical Science
Citations in the corpus
- Nanocomposite Hydrogels: 3D Polymer-Nanoparticle Synergies for On-Demand Drug Delivery. (2015, background): “The development of multifunctional polymer-based matrices for controlled drug delivery purposes has been the subject of intense research during the last six decades.(1) After initial efforts for understanding drug release mechanisms and for maintaining a constant drug concentration in the”
- Nanotechnology: A Revolution in Modern Industry (2023, background): “With this, it could be predicted that soon, nanomedicine will be the foremost research interest for the coming generation of biologists to study the useful impacts and risks that might be associated with them [99].”
- Controlled Drug Delivery Systems: Current Status and Future Directions (2021, background): “In the last decade of the second generation, nanoparticles that target the gene and the tumour were studied [47].”
- Advances in drug delivery systems, challenges and future directions (2023, background): “Although this nanotechnology-based DDS demonstrated high efficacy in controlling tumor growth in animal models, the FDA only approved a few drugs [31,39].”