Perforin and granzymes: function, dysfunction and human pathology

By I. Voskoboinik, James C. Whisstock, J. Trapani. Nature reviews. Immunology, 2015

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CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 (2022, background): “It is well known that CTLs kill targets via the perforin-granzyme-caspase-mediated apoptosis (Voskoboinik et al., 2015).”
How Do Cytotoxic Lymphocytes Kill Cancer Cells? (2015, background): “However, additional GZMs with possible functional significance (in total 5 in humans and 10 in mice) and other cytoplasmic granuleassociated molecules like the human-specific protein granulysin (17) have been described, though their biologic functions during cancer immunity and immunotherapy have no”
MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions (2019, background): “Activation of the T cell effector program ultimately depends on expression of units of the cytotoxic granule (granzymes, cathepsins, granulysin) and of the machinery required for perforating target cells (e.g., perforin) [45].”
Role of pyroptosis in inflammation and cancer (2022, background): “Furthermore, cytotoxic lymphocyte-mediated immunity is dependent on granzymes, which can enhance antitumor immunity and may be a potential candidate targeted site for tumor treatments [121, 123] (Fig.”