Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
By Guoyou Huang, Fei Li, Xin Zhao, Yufei Ma, Yuhui Li, Min Lin, Guorui Jin, Tianjian Lu, G. Genin, Feng Xu. Chemical Reviews, 2017
700 citations recorded by the source corpus.
The cell microenvironment has emerged as a key determinant of cell behavior and function in development, physiology, and pathophysiology. Extracellular matrix (ECM) within the cell microenvironment serves not only as a structural foundation for cells, but also as a source of three-dimensional (3D) biochemical and biophysical cues that trigger and regulate cell behaviors. Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, fueling a surge in the development of functional and biomimetic materials for engineering the 3D cell microenvironment. Progress in the design of such materials has improved control of cell behaviors in 3D and advanced the fields of tissue regeneration, in vitro tissue models, large-scale cell differentiation, immunotherapy, and gene therapy. However, the field is still in its infancy, and discoveries about the nature of cell-microenvironment interactions continue to overturn much early progress in the field. Key challenges continue to be dissecting the roles of chemistry, structure, mechanics, and electrophysiology in the cell microenvironment, and understanding and harnessing the roles of periodicity and drift in these factors. This review encapsulates where recent advances appear to leave the ever-shifting state of the art, and highlights areas in which substantial potential and uncertainty remain.
Subfields: Biomedical Engineering, Cell Biology
View Paper: https://www.semanticscholar.org/paper/9d5fe62d1427b613d8f2a982fc619b7bee4250b2
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In Biomedical Engineering
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Citations in the corpus
- Tissue Engineering for Clean Meat Production (2019, background): “Chitosan provide similar structure to GAGs, and can provide antibacterial properties (Fedorovich et al., 2007), however like alginate, it requires chemical modification to facilitate cell adhesion and biodegradability (Huang et al., 2017).”